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一 | Sputnik spoke with Dr. D. B. Bhaaskara, CEO of the multinational company Roerich Healthcare, about the current state of pharma trade with Russia.,Sputnik: Can you explain the current state of pharma supplies to Russia?,D. B. Bhaaskara: Currently, pharmaceutical shipments of Indian firms to Russia are at the same level even after the sanctions. But, there are many proposals (supplies) that Russians are not getting from the European Union. Russians are looking for these materials (chemicals, excipients, APIs [Active Pharmaceutical Ingredients]) with several Indian manufacturers. They have to develop links with Indian firms. There are many proposals from Russia - these proposals are under consideration from the Indian side.,Sputnik: There were reports of delayed payments from Russia initially after sanctions. As we see, trade has jumped manifold in the energy and fertilizer sectors. Do you think payment issues have been resolved in other sectors as well?,D. B. Bhaaskara: Several Indian companies have signed contracts in yuan, which means they are ready to receive payment in China's yuan. Still, the preferred mode of settlement is in the Indian rupee. As export procedures closed successfully in USD/euro/INR, Russians set aside yuan contracts.,My company is receiving regular payment without any delay in Indian rupees or USD or sometimes in euros.,Sputnik: What about logistical issues, as sanctions hit the shipping sector?,D. B. Bhaaskara: The logistical issues are still there because few airlines — namely Aeroflot, Emirates, Qatar, and Turkish — are available for transportation. Transportation costs are slightly high because of no regular cargo consignments. They vary between $8-12 per kg compared to $5 per kg in a normal situation.,Cargo sea shipment is still in a mess. The only port in Gujarat accepts Russian shipping. Here again, the container price is very, very high. We have to pay anything between $9,000 - 12,000 for a container. When there was no conflict or sanctions, it was $2,500 per container.,We have tried to send our shipments via Iran. So, from Gujarat port, the shipment reaches an Iranian port, and from there, it goes via road or rail to Moscow. But, it is taking a much longer time. In general, it is supposed to arrive in 30-40 days, but on an experimental basis, some companies sent their materials via the Iran route, [and they are] still on their way even after two months.,Shanghai is very crowded and has also been hit by the pandemic, making it unsuitable for us. So, the only problem right now is logistics; there is no payment issue.,Some Russian companies have an account with European banks operating in Russia dealing in oil and gas payments. Those banks are being used to send money anywhere worldwide, even with sanctions.,Sputnik: Western firms intended to withdraw their operations in Russia in response to Moscow's special military operation. Do you see some significant investments from Indian pharma companies in Russia to fill the vacuum created by the west?,D. B. Bhaaskara: There are long-pending proposals from a couple of governors, such as [in] Volgograd and Kazan, inviting India's major pharma companies to set up manufacturing units in their region. But, due to the pandemic, nothing moved ahead.,A delegation will be going to Russia to explore the opportunities in Russia in July. A few Indian companies, such as Sun Pharma and Advance Pharma, have manufacturing units in Russia doing finished formulations.,Hopefully, some new companies are interested in setting up units there now. But, Russia is looking to scale up raw material manufacturing, e.g., API. For this, much homework related to regulation should be done between the two governments, especially under sanctions.,Also, big companies such as Sun Pharma, Aurbindo, and Dr. Reddy, all with significant exposure to the US market, may try to avoid investing in Russia because they are scared of the risk associated with sanctions.,Medium-scale companies can come forward to set up raw material (API) manufacturing in Russia. However, it is unclear whether Indian workers/professionals can go and work in Russia. Setting up a new unit in unknown topography with a different language and culture is a little complicated. A lot of these questions are unanswered.。 随着医学界对雄激素性秃发发病机制认识不断完善,一种新的治疗思路正在临床逐渐形成——既然影响毛囊的重要雄激素代谢主要发生在头皮局部,那么药物是否也可以更加精准地作用于头皮? 8月22日,在上海举行的杨国亮皮肤病学大会上,多位毛发医学专家围绕这一问题进行了讨论。 专家介绍,多数雄激素性秃发患者并不存在明显的全身雄激素升高,其重要发病环节之一,是头皮毛囊局部的睾酮在5α-还原酶作用下转化为双氢睾酮,并持续作用于敏感毛囊。

二 | 传统非那雄胺主要采用口服方式,通过抑制5α-还原酶减少双氢睾酮生成。

三 | 随着药物递送和制剂技术发展,过去一年,外用非那雄胺喷雾剂在中国批准上市,逐步进入临床应用,使雄激素性秃发的治疗在过去一年里由全身系统性用药进一步延伸到头皮局部用药。 这并非简单的“片剂变喷雾”,而是反映了皮肤科治疗逐渐走向精准化和局部化的趋势。 相关临床研究显示,外用非那雄胺喷雾剂型可以降低头皮局部双氢睾酮水平,并改善部分患者的毛发生长情况,同时对全身激素水平的影响相对较小。 专家表示,新治疗方式并非意味着传统口服治疗将被取代,而是医生和患者在疗效、安全性和患者个体需求之间增加了一种新的选择。

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